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8-ohdg (8-hydroxydeoxyguanosine) elisa kit  (Guangzhou JET Bio-Filtration)
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Guangzhou JET Bio-Filtration 8-ohdg (8-hydroxydeoxyguanosine) elisa kit
8 Ohdg (8 Hydroxydeoxyguanosine) Elisa Kit, supplied by Guangzhou JET Bio-Filtration, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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8 ohdg antibody  (MedChemExpress)
94
MedChemExpress 8 ohdg antibody
Aluminum exposure triggers mitochondrial dysfunction, oxidative damage accumulation and apoptosis in mouse zygotes (A) Representative images of mitochondrial distribution in zygotes of the control and treatment groups by immunofluorescence staining. Red, mitochondria; blue, DNA. Scale bars, 20 μm. (B) Relative fluorescence intensity and abnormal rate of mitochondria. The relative fluorescence intensity: control, n = 47; AlCl 3 , n = 50; ∗∗ p < 0.005; abnormal rate: control, n = 47; AlCl 3 , n = 50; ∗∗∗ p < 0.0005. (C) TMRE levels in zygotes of the control and treatment groups by immunofluorescence staining. Red, TMRE; blue, DNA. Scale bars, 20 μm. (D) Relative fluorescence intensity of TMRE. Control, n = 45; AlCl 3 , n = 46; ∗ p < 0.05. (E) ROS-positive rate in zygotes of the control and treatment groups at 5.5 h, 6 h, 9 h, and 12 h post-fertilization by immunofluorescence staining. Green, ROS. Scale bars, 80 μm. (5.5 h corresponds to 30 min after AlCl 3 treatment, 6 h to 1 h, 9 h–4 h, and 12 h–7 h after AlCl 3 treatment). (F) ROS-positive rate in zygotes at different time points post-fertilization. 5.5 h: control, n = 39; AlCl 3 , n = 38; ∗∗∗ p < 0.0005; 6 h: control, n = 45; AlCl 3 , n = 47; ∗∗ p < 0.005; 9 h: control, n = 41; AlCl 3 , n = 42; ∗ p < 0.05; 12 h: control, n = 38; AlCl 3 , n = 46; ∗∗∗∗ p < 0.0001. (G) The mRNA expression level of Cox1 . ∗∗∗ p < 0.0005. <t>(H)</t> <t>8-OHdG</t> levels in zygotes of the control and treatment groups by immunofluorescence staining. Red, 8-OHdG; blue, DNA. Scale bars, 20 μm. (I) Relative fluorescence intensity of 8-OHdG. Control, n = 41; AlCl 3 , n = 39; ∗∗ p < 0.005. (J) The 4-HNE levels in zygotes of the control and treatment groups by immunofluorescence staining. Red, 4-HNE; blue, DNA. Scale bars, 20 μm. (K) Relative fluorescence intensity of 4-HNE. Control, n = 39; AlCl 3 , n = 41; ∗∗∗∗ p < 0.0001. (L) The mRNA expression levels of oxidative stress-related genes. ∗∗ p < 0.005, ∗∗ p < 0.01, ∗ p < 0.05, ∗∗∗ p < 0.0005. (M) Representative images of early apoptosis in control and AlCl 3 -exposed groups by immunofluorescence staining. Green, annexin-V. Scale bars, 20 μm. (N) Apoptosis rate of zygotes. Control, n = 56; AlCl 3 , n = 50; ∗∗ p < 0.005. (O) The mRNA expression levels of apoptosis-related genes. ∗∗ p < 0.01, ∗∗ p < 0.005, ∗ p < 0.05. Data are presented as mean ± SEM. All experiments were performed in three independent biological replicates, with three technical replicates per biological replicate; mouse zygotes were used as research subjects. n represents the number of zygotes analyzed. Statistical analysis was performed using paired t tests. Asterisks indicate statistical significance: ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001, ∗∗∗∗ p < 0.0001.
8 Ohdg Antibody, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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rabbit anti 8 ohdg  (Bioss)
96
Bioss rabbit anti 8 ohdg
Aluminum exposure triggers mitochondrial dysfunction, oxidative damage accumulation and apoptosis in mouse zygotes (A) Representative images of mitochondrial distribution in zygotes of the control and treatment groups by immunofluorescence staining. Red, mitochondria; blue, DNA. Scale bars, 20 μm. (B) Relative fluorescence intensity and abnormal rate of mitochondria. The relative fluorescence intensity: control, n = 47; AlCl 3 , n = 50; ∗∗ p < 0.005; abnormal rate: control, n = 47; AlCl 3 , n = 50; ∗∗∗ p < 0.0005. (C) TMRE levels in zygotes of the control and treatment groups by immunofluorescence staining. Red, TMRE; blue, DNA. Scale bars, 20 μm. (D) Relative fluorescence intensity of TMRE. Control, n = 45; AlCl 3 , n = 46; ∗ p < 0.05. (E) ROS-positive rate in zygotes of the control and treatment groups at 5.5 h, 6 h, 9 h, and 12 h post-fertilization by immunofluorescence staining. Green, ROS. Scale bars, 80 μm. (5.5 h corresponds to 30 min after AlCl 3 treatment, 6 h to 1 h, 9 h–4 h, and 12 h–7 h after AlCl 3 treatment). (F) ROS-positive rate in zygotes at different time points post-fertilization. 5.5 h: control, n = 39; AlCl 3 , n = 38; ∗∗∗ p < 0.0005; 6 h: control, n = 45; AlCl 3 , n = 47; ∗∗ p < 0.005; 9 h: control, n = 41; AlCl 3 , n = 42; ∗ p < 0.05; 12 h: control, n = 38; AlCl 3 , n = 46; ∗∗∗∗ p < 0.0001. (G) The mRNA expression level of Cox1 . ∗∗∗ p < 0.0005. <t>(H)</t> <t>8-OHdG</t> levels in zygotes of the control and treatment groups by immunofluorescence staining. Red, 8-OHdG; blue, DNA. Scale bars, 20 μm. (I) Relative fluorescence intensity of 8-OHdG. Control, n = 41; AlCl 3 , n = 39; ∗∗ p < 0.005. (J) The 4-HNE levels in zygotes of the control and treatment groups by immunofluorescence staining. Red, 4-HNE; blue, DNA. Scale bars, 20 μm. (K) Relative fluorescence intensity of 4-HNE. Control, n = 39; AlCl 3 , n = 41; ∗∗∗∗ p < 0.0001. (L) The mRNA expression levels of oxidative stress-related genes. ∗∗ p < 0.005, ∗∗ p < 0.01, ∗ p < 0.05, ∗∗∗ p < 0.0005. (M) Representative images of early apoptosis in control and AlCl 3 -exposed groups by immunofluorescence staining. Green, annexin-V. Scale bars, 20 μm. (N) Apoptosis rate of zygotes. Control, n = 56; AlCl 3 , n = 50; ∗∗ p < 0.005. (O) The mRNA expression levels of apoptosis-related genes. ∗∗ p < 0.01, ∗∗ p < 0.005, ∗ p < 0.05. Data are presented as mean ± SEM. All experiments were performed in three independent biological replicates, with three technical replicates per biological replicate; mouse zygotes were used as research subjects. n represents the number of zygotes analyzed. Statistical analysis was performed using paired t tests. Asterisks indicate statistical significance: ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001, ∗∗∗∗ p < 0.0001.
Rabbit Anti 8 Ohdg, supplied by Bioss, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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elisa reagent  (Elabscience Biotechnology)
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Elabscience Biotechnology elisa reagent
Aluminum exposure triggers mitochondrial dysfunction, oxidative damage accumulation and apoptosis in mouse zygotes (A) Representative images of mitochondrial distribution in zygotes of the control and treatment groups by immunofluorescence staining. Red, mitochondria; blue, DNA. Scale bars, 20 μm. (B) Relative fluorescence intensity and abnormal rate of mitochondria. The relative fluorescence intensity: control, n = 47; AlCl 3 , n = 50; ∗∗ p < 0.005; abnormal rate: control, n = 47; AlCl 3 , n = 50; ∗∗∗ p < 0.0005. (C) TMRE levels in zygotes of the control and treatment groups by immunofluorescence staining. Red, TMRE; blue, DNA. Scale bars, 20 μm. (D) Relative fluorescence intensity of TMRE. Control, n = 45; AlCl 3 , n = 46; ∗ p < 0.05. (E) ROS-positive rate in zygotes of the control and treatment groups at 5.5 h, 6 h, 9 h, and 12 h post-fertilization by immunofluorescence staining. Green, ROS. Scale bars, 80 μm. (5.5 h corresponds to 30 min after AlCl 3 treatment, 6 h to 1 h, 9 h–4 h, and 12 h–7 h after AlCl 3 treatment). (F) ROS-positive rate in zygotes at different time points post-fertilization. 5.5 h: control, n = 39; AlCl 3 , n = 38; ∗∗∗ p < 0.0005; 6 h: control, n = 45; AlCl 3 , n = 47; ∗∗ p < 0.005; 9 h: control, n = 41; AlCl 3 , n = 42; ∗ p < 0.05; 12 h: control, n = 38; AlCl 3 , n = 46; ∗∗∗∗ p < 0.0001. (G) The mRNA expression level of Cox1 . ∗∗∗ p < 0.0005. <t>(H)</t> <t>8-OHdG</t> levels in zygotes of the control and treatment groups by immunofluorescence staining. Red, 8-OHdG; blue, DNA. Scale bars, 20 μm. (I) Relative fluorescence intensity of 8-OHdG. Control, n = 41; AlCl 3 , n = 39; ∗∗ p < 0.005. (J) The 4-HNE levels in zygotes of the control and treatment groups by immunofluorescence staining. Red, 4-HNE; blue, DNA. Scale bars, 20 μm. (K) Relative fluorescence intensity of 4-HNE. Control, n = 39; AlCl 3 , n = 41; ∗∗∗∗ p < 0.0001. (L) The mRNA expression levels of oxidative stress-related genes. ∗∗ p < 0.005, ∗∗ p < 0.01, ∗ p < 0.05, ∗∗∗ p < 0.0005. (M) Representative images of early apoptosis in control and AlCl 3 -exposed groups by immunofluorescence staining. Green, annexin-V. Scale bars, 20 μm. (N) Apoptosis rate of zygotes. Control, n = 56; AlCl 3 , n = 50; ∗∗ p < 0.005. (O) The mRNA expression levels of apoptosis-related genes. ∗∗ p < 0.01, ∗∗ p < 0.005, ∗ p < 0.05. Data are presented as mean ± SEM. All experiments were performed in three independent biological replicates, with three technical replicates per biological replicate; mouse zygotes were used as research subjects. n represents the number of zygotes analyzed. Statistical analysis was performed using paired t tests. Asterisks indicate statistical significance: ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001, ∗∗∗∗ p < 0.0001.
Elisa Reagent, supplied by Elabscience Biotechnology, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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hy p81140  (MedChemExpress)
94
MedChemExpress hy p81140
Aluminum exposure triggers mitochondrial dysfunction, oxidative damage accumulation and apoptosis in mouse zygotes (A) Representative images of mitochondrial distribution in zygotes of the control and treatment groups by immunofluorescence staining. Red, mitochondria; blue, DNA. Scale bars, 20 μm. (B) Relative fluorescence intensity and abnormal rate of mitochondria. The relative fluorescence intensity: control, n = 47; AlCl 3 , n = 50; ∗∗ p < 0.005; abnormal rate: control, n = 47; AlCl 3 , n = 50; ∗∗∗ p < 0.0005. (C) TMRE levels in zygotes of the control and treatment groups by immunofluorescence staining. Red, TMRE; blue, DNA. Scale bars, 20 μm. (D) Relative fluorescence intensity of TMRE. Control, n = 45; AlCl 3 , n = 46; ∗ p < 0.05. (E) ROS-positive rate in zygotes of the control and treatment groups at 5.5 h, 6 h, 9 h, and 12 h post-fertilization by immunofluorescence staining. Green, ROS. Scale bars, 80 μm. (5.5 h corresponds to 30 min after AlCl 3 treatment, 6 h to 1 h, 9 h–4 h, and 12 h–7 h after AlCl 3 treatment). (F) ROS-positive rate in zygotes at different time points post-fertilization. 5.5 h: control, n = 39; AlCl 3 , n = 38; ∗∗∗ p < 0.0005; 6 h: control, n = 45; AlCl 3 , n = 47; ∗∗ p < 0.005; 9 h: control, n = 41; AlCl 3 , n = 42; ∗ p < 0.05; 12 h: control, n = 38; AlCl 3 , n = 46; ∗∗∗∗ p < 0.0001. (G) The mRNA expression level of Cox1 . ∗∗∗ p < 0.0005. <t>(H)</t> <t>8-OHdG</t> levels in zygotes of the control and treatment groups by immunofluorescence staining. Red, 8-OHdG; blue, DNA. Scale bars, 20 μm. (I) Relative fluorescence intensity of 8-OHdG. Control, n = 41; AlCl 3 , n = 39; ∗∗ p < 0.005. (J) The 4-HNE levels in zygotes of the control and treatment groups by immunofluorescence staining. Red, 4-HNE; blue, DNA. Scale bars, 20 μm. (K) Relative fluorescence intensity of 4-HNE. Control, n = 39; AlCl 3 , n = 41; ∗∗∗∗ p < 0.0001. (L) The mRNA expression levels of oxidative stress-related genes. ∗∗ p < 0.005, ∗∗ p < 0.01, ∗ p < 0.05, ∗∗∗ p < 0.0005. (M) Representative images of early apoptosis in control and AlCl 3 -exposed groups by immunofluorescence staining. Green, annexin-V. Scale bars, 20 μm. (N) Apoptosis rate of zygotes. Control, n = 56; AlCl 3 , n = 50; ∗∗ p < 0.005. (O) The mRNA expression levels of apoptosis-related genes. ∗∗ p < 0.01, ∗∗ p < 0.005, ∗ p < 0.05. Data are presented as mean ± SEM. All experiments were performed in three independent biological replicates, with three technical replicates per biological replicate; mouse zygotes were used as research subjects. n represents the number of zygotes analyzed. Statistical analysis was performed using paired t tests. Asterisks indicate statistical significance: ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001, ∗∗∗∗ p < 0.0001.
Hy P81140, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/8+ohdg/8-OHdG+(DNA%2FRNA+Damage)+Antibody/10__1002_slash_inmd__70140-110-11-12
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bs 1278r  (Bioss)
96
Bioss bs 1278r
Aluminum exposure triggers mitochondrial dysfunction, oxidative damage accumulation and apoptosis in mouse zygotes (A) Representative images of mitochondrial distribution in zygotes of the control and treatment groups by immunofluorescence staining. Red, mitochondria; blue, DNA. Scale bars, 20 μm. (B) Relative fluorescence intensity and abnormal rate of mitochondria. The relative fluorescence intensity: control, n = 47; AlCl 3 , n = 50; ∗∗ p < 0.005; abnormal rate: control, n = 47; AlCl 3 , n = 50; ∗∗∗ p < 0.0005. (C) TMRE levels in zygotes of the control and treatment groups by immunofluorescence staining. Red, TMRE; blue, DNA. Scale bars, 20 μm. (D) Relative fluorescence intensity of TMRE. Control, n = 45; AlCl 3 , n = 46; ∗ p < 0.05. (E) ROS-positive rate in zygotes of the control and treatment groups at 5.5 h, 6 h, 9 h, and 12 h post-fertilization by immunofluorescence staining. Green, ROS. Scale bars, 80 μm. (5.5 h corresponds to 30 min after AlCl 3 treatment, 6 h to 1 h, 9 h–4 h, and 12 h–7 h after AlCl 3 treatment). (F) ROS-positive rate in zygotes at different time points post-fertilization. 5.5 h: control, n = 39; AlCl 3 , n = 38; ∗∗∗ p < 0.0005; 6 h: control, n = 45; AlCl 3 , n = 47; ∗∗ p < 0.005; 9 h: control, n = 41; AlCl 3 , n = 42; ∗ p < 0.05; 12 h: control, n = 38; AlCl 3 , n = 46; ∗∗∗∗ p < 0.0001. (G) The mRNA expression level of Cox1 . ∗∗∗ p < 0.0005. <t>(H)</t> <t>8-OHdG</t> levels in zygotes of the control and treatment groups by immunofluorescence staining. Red, 8-OHdG; blue, DNA. Scale bars, 20 μm. (I) Relative fluorescence intensity of 8-OHdG. Control, n = 41; AlCl 3 , n = 39; ∗∗ p < 0.005. (J) The 4-HNE levels in zygotes of the control and treatment groups by immunofluorescence staining. Red, 4-HNE; blue, DNA. Scale bars, 20 μm. (K) Relative fluorescence intensity of 4-HNE. Control, n = 39; AlCl 3 , n = 41; ∗∗∗∗ p < 0.0001. (L) The mRNA expression levels of oxidative stress-related genes. ∗∗ p < 0.005, ∗∗ p < 0.01, ∗ p < 0.05, ∗∗∗ p < 0.0005. (M) Representative images of early apoptosis in control and AlCl 3 -exposed groups by immunofluorescence staining. Green, annexin-V. Scale bars, 20 μm. (N) Apoptosis rate of zygotes. Control, n = 56; AlCl 3 , n = 50; ∗∗ p < 0.005. (O) The mRNA expression levels of apoptosis-related genes. ∗∗ p < 0.01, ∗∗ p < 0.005, ∗ p < 0.05. Data are presented as mean ± SEM. All experiments were performed in three independent biological replicates, with three technical replicates per biological replicate; mouse zygotes were used as research subjects. n represents the number of zygotes analyzed. Statistical analysis was performed using paired t tests. Asterisks indicate statistical significance: ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001, ∗∗∗∗ p < 0.0001.
Bs 1278r, supplied by Bioss, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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8 ohdg  (MedChemExpress)
94
MedChemExpress 8 ohdg
Aluminum exposure triggers mitochondrial dysfunction, oxidative damage accumulation and apoptosis in mouse zygotes (A) Representative images of mitochondrial distribution in zygotes of the control and treatment groups by immunofluorescence staining. Red, mitochondria; blue, DNA. Scale bars, 20 μm. (B) Relative fluorescence intensity and abnormal rate of mitochondria. The relative fluorescence intensity: control, n = 47; AlCl 3 , n = 50; ∗∗ p < 0.005; abnormal rate: control, n = 47; AlCl 3 , n = 50; ∗∗∗ p < 0.0005. (C) TMRE levels in zygotes of the control and treatment groups by immunofluorescence staining. Red, TMRE; blue, DNA. Scale bars, 20 μm. (D) Relative fluorescence intensity of TMRE. Control, n = 45; AlCl 3 , n = 46; ∗ p < 0.05. (E) ROS-positive rate in zygotes of the control and treatment groups at 5.5 h, 6 h, 9 h, and 12 h post-fertilization by immunofluorescence staining. Green, ROS. Scale bars, 80 μm. (5.5 h corresponds to 30 min after AlCl 3 treatment, 6 h to 1 h, 9 h–4 h, and 12 h–7 h after AlCl 3 treatment). (F) ROS-positive rate in zygotes at different time points post-fertilization. 5.5 h: control, n = 39; AlCl 3 , n = 38; ∗∗∗ p < 0.0005; 6 h: control, n = 45; AlCl 3 , n = 47; ∗∗ p < 0.005; 9 h: control, n = 41; AlCl 3 , n = 42; ∗ p < 0.05; 12 h: control, n = 38; AlCl 3 , n = 46; ∗∗∗∗ p < 0.0001. (G) The mRNA expression level of Cox1 . ∗∗∗ p < 0.0005. <t>(H)</t> <t>8-OHdG</t> levels in zygotes of the control and treatment groups by immunofluorescence staining. Red, 8-OHdG; blue, DNA. Scale bars, 20 μm. (I) Relative fluorescence intensity of 8-OHdG. Control, n = 41; AlCl 3 , n = 39; ∗∗ p < 0.005. (J) The 4-HNE levels in zygotes of the control and treatment groups by immunofluorescence staining. Red, 4-HNE; blue, DNA. Scale bars, 20 μm. (K) Relative fluorescence intensity of 4-HNE. Control, n = 39; AlCl 3 , n = 41; ∗∗∗∗ p < 0.0001. (L) The mRNA expression levels of oxidative stress-related genes. ∗∗ p < 0.005, ∗∗ p < 0.01, ∗ p < 0.05, ∗∗∗ p < 0.0005. (M) Representative images of early apoptosis in control and AlCl 3 -exposed groups by immunofluorescence staining. Green, annexin-V. Scale bars, 20 μm. (N) Apoptosis rate of zygotes. Control, n = 56; AlCl 3 , n = 50; ∗∗ p < 0.005. (O) The mRNA expression levels of apoptosis-related genes. ∗∗ p < 0.01, ∗∗ p < 0.005, ∗ p < 0.05. Data are presented as mean ± SEM. All experiments were performed in three independent biological replicates, with three technical replicates per biological replicate; mouse zygotes were used as research subjects. n represents the number of zygotes analyzed. Statistical analysis was performed using paired t tests. Asterisks indicate statistical significance: ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001, ∗∗∗∗ p < 0.0001.
8 Ohdg, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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8 ohdg  (Bioss)
96
Bioss 8 ohdg
Aluminum exposure triggers mitochondrial dysfunction, oxidative damage accumulation and apoptosis in mouse zygotes (A) Representative images of mitochondrial distribution in zygotes of the control and treatment groups by immunofluorescence staining. Red, mitochondria; blue, DNA. Scale bars, 20 μm. (B) Relative fluorescence intensity and abnormal rate of mitochondria. The relative fluorescence intensity: control, n = 47; AlCl 3 , n = 50; ∗∗ p < 0.005; abnormal rate: control, n = 47; AlCl 3 , n = 50; ∗∗∗ p < 0.0005. (C) TMRE levels in zygotes of the control and treatment groups by immunofluorescence staining. Red, TMRE; blue, DNA. Scale bars, 20 μm. (D) Relative fluorescence intensity of TMRE. Control, n = 45; AlCl 3 , n = 46; ∗ p < 0.05. (E) ROS-positive rate in zygotes of the control and treatment groups at 5.5 h, 6 h, 9 h, and 12 h post-fertilization by immunofluorescence staining. Green, ROS. Scale bars, 80 μm. (5.5 h corresponds to 30 min after AlCl 3 treatment, 6 h to 1 h, 9 h–4 h, and 12 h–7 h after AlCl 3 treatment). (F) ROS-positive rate in zygotes at different time points post-fertilization. 5.5 h: control, n = 39; AlCl 3 , n = 38; ∗∗∗ p < 0.0005; 6 h: control, n = 45; AlCl 3 , n = 47; ∗∗ p < 0.005; 9 h: control, n = 41; AlCl 3 , n = 42; ∗ p < 0.05; 12 h: control, n = 38; AlCl 3 , n = 46; ∗∗∗∗ p < 0.0001. (G) The mRNA expression level of Cox1 . ∗∗∗ p < 0.0005. <t>(H)</t> <t>8-OHdG</t> levels in zygotes of the control and treatment groups by immunofluorescence staining. Red, 8-OHdG; blue, DNA. Scale bars, 20 μm. (I) Relative fluorescence intensity of 8-OHdG. Control, n = 41; AlCl 3 , n = 39; ∗∗ p < 0.005. (J) The 4-HNE levels in zygotes of the control and treatment groups by immunofluorescence staining. Red, 4-HNE; blue, DNA. Scale bars, 20 μm. (K) Relative fluorescence intensity of 4-HNE. Control, n = 39; AlCl 3 , n = 41; ∗∗∗∗ p < 0.0001. (L) The mRNA expression levels of oxidative stress-related genes. ∗∗ p < 0.005, ∗∗ p < 0.01, ∗ p < 0.05, ∗∗∗ p < 0.0005. (M) Representative images of early apoptosis in control and AlCl 3 -exposed groups by immunofluorescence staining. Green, annexin-V. Scale bars, 20 μm. (N) Apoptosis rate of zygotes. Control, n = 56; AlCl 3 , n = 50; ∗∗ p < 0.005. (O) The mRNA expression levels of apoptosis-related genes. ∗∗ p < 0.01, ∗∗ p < 0.005, ∗ p < 0.05. Data are presented as mean ± SEM. All experiments were performed in three independent biological replicates, with three technical replicates per biological replicate; mouse zygotes were used as research subjects. n represents the number of zygotes analyzed. Statistical analysis was performed using paired t tests. Asterisks indicate statistical significance: ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001, ∗∗∗∗ p < 0.0001.
8 Ohdg, supplied by Bioss, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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e el 0028  (Elabscience Biotechnology)
96
Elabscience Biotechnology e el 0028
Aluminum exposure triggers mitochondrial dysfunction, oxidative damage accumulation and apoptosis in mouse zygotes (A) Representative images of mitochondrial distribution in zygotes of the control and treatment groups by immunofluorescence staining. Red, mitochondria; blue, DNA. Scale bars, 20 μm. (B) Relative fluorescence intensity and abnormal rate of mitochondria. The relative fluorescence intensity: control, n = 47; AlCl 3 , n = 50; ∗∗ p < 0.005; abnormal rate: control, n = 47; AlCl 3 , n = 50; ∗∗∗ p < 0.0005. (C) TMRE levels in zygotes of the control and treatment groups by immunofluorescence staining. Red, TMRE; blue, DNA. Scale bars, 20 μm. (D) Relative fluorescence intensity of TMRE. Control, n = 45; AlCl 3 , n = 46; ∗ p < 0.05. (E) ROS-positive rate in zygotes of the control and treatment groups at 5.5 h, 6 h, 9 h, and 12 h post-fertilization by immunofluorescence staining. Green, ROS. Scale bars, 80 μm. (5.5 h corresponds to 30 min after AlCl 3 treatment, 6 h to 1 h, 9 h–4 h, and 12 h–7 h after AlCl 3 treatment). (F) ROS-positive rate in zygotes at different time points post-fertilization. 5.5 h: control, n = 39; AlCl 3 , n = 38; ∗∗∗ p < 0.0005; 6 h: control, n = 45; AlCl 3 , n = 47; ∗∗ p < 0.005; 9 h: control, n = 41; AlCl 3 , n = 42; ∗ p < 0.05; 12 h: control, n = 38; AlCl 3 , n = 46; ∗∗∗∗ p < 0.0001. (G) The mRNA expression level of Cox1 . ∗∗∗ p < 0.0005. <t>(H)</t> <t>8-OHdG</t> levels in zygotes of the control and treatment groups by immunofluorescence staining. Red, 8-OHdG; blue, DNA. Scale bars, 20 μm. (I) Relative fluorescence intensity of 8-OHdG. Control, n = 41; AlCl 3 , n = 39; ∗∗ p < 0.005. (J) The 4-HNE levels in zygotes of the control and treatment groups by immunofluorescence staining. Red, 4-HNE; blue, DNA. Scale bars, 20 μm. (K) Relative fluorescence intensity of 4-HNE. Control, n = 39; AlCl 3 , n = 41; ∗∗∗∗ p < 0.0001. (L) The mRNA expression levels of oxidative stress-related genes. ∗∗ p < 0.005, ∗∗ p < 0.01, ∗ p < 0.05, ∗∗∗ p < 0.0005. (M) Representative images of early apoptosis in control and AlCl 3 -exposed groups by immunofluorescence staining. Green, annexin-V. Scale bars, 20 μm. (N) Apoptosis rate of zygotes. Control, n = 56; AlCl 3 , n = 50; ∗∗ p < 0.005. (O) The mRNA expression levels of apoptosis-related genes. ∗∗ p < 0.01, ∗∗ p < 0.005, ∗ p < 0.05. Data are presented as mean ± SEM. All experiments were performed in three independent biological replicates, with three technical replicates per biological replicate; mouse zygotes were used as research subjects. n represents the number of zygotes analyzed. Statistical analysis was performed using paired t tests. Asterisks indicate statistical significance: ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001, ∗∗∗∗ p < 0.0001.
E El 0028, supplied by Elabscience Biotechnology, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Aluminum exposure triggers mitochondrial dysfunction, oxidative damage accumulation and apoptosis in mouse zygotes (A) Representative images of mitochondrial distribution in zygotes of the control and treatment groups by immunofluorescence staining. Red, mitochondria; blue, DNA. Scale bars, 20 μm. (B) Relative fluorescence intensity and abnormal rate of mitochondria. The relative fluorescence intensity: control, n = 47; AlCl 3 , n = 50; ∗∗ p < 0.005; abnormal rate: control, n = 47; AlCl 3 , n = 50; ∗∗∗ p < 0.0005. (C) TMRE levels in zygotes of the control and treatment groups by immunofluorescence staining. Red, TMRE; blue, DNA. Scale bars, 20 μm. (D) Relative fluorescence intensity of TMRE. Control, n = 45; AlCl 3 , n = 46; ∗ p < 0.05. (E) ROS-positive rate in zygotes of the control and treatment groups at 5.5 h, 6 h, 9 h, and 12 h post-fertilization by immunofluorescence staining. Green, ROS. Scale bars, 80 μm. (5.5 h corresponds to 30 min after AlCl 3 treatment, 6 h to 1 h, 9 h–4 h, and 12 h–7 h after AlCl 3 treatment). (F) ROS-positive rate in zygotes at different time points post-fertilization. 5.5 h: control, n = 39; AlCl 3 , n = 38; ∗∗∗ p < 0.0005; 6 h: control, n = 45; AlCl 3 , n = 47; ∗∗ p < 0.005; 9 h: control, n = 41; AlCl 3 , n = 42; ∗ p < 0.05; 12 h: control, n = 38; AlCl 3 , n = 46; ∗∗∗∗ p < 0.0001. (G) The mRNA expression level of Cox1 . ∗∗∗ p < 0.0005. <t>(H)</t> <t>8-OHdG</t> levels in zygotes of the control and treatment groups by immunofluorescence staining. Red, 8-OHdG; blue, DNA. Scale bars, 20 μm. (I) Relative fluorescence intensity of 8-OHdG. Control, n = 41; AlCl 3 , n = 39; ∗∗ p < 0.005. (J) The 4-HNE levels in zygotes of the control and treatment groups by immunofluorescence staining. Red, 4-HNE; blue, DNA. Scale bars, 20 μm. (K) Relative fluorescence intensity of 4-HNE. Control, n = 39; AlCl 3 , n = 41; ∗∗∗∗ p < 0.0001. (L) The mRNA expression levels of oxidative stress-related genes. ∗∗ p < 0.005, ∗∗ p < 0.01, ∗ p < 0.05, ∗∗∗ p < 0.0005. (M) Representative images of early apoptosis in control and AlCl 3 -exposed groups by immunofluorescence staining. Green, annexin-V. Scale bars, 20 μm. (N) Apoptosis rate of zygotes. Control, n = 56; AlCl 3 , n = 50; ∗∗ p < 0.005. (O) The mRNA expression levels of apoptosis-related genes. ∗∗ p < 0.01, ∗∗ p < 0.005, ∗ p < 0.05. Data are presented as mean ± SEM. All experiments were performed in three independent biological replicates, with three technical replicates per biological replicate; mouse zygotes were used as research subjects. n represents the number of zygotes analyzed. Statistical analysis was performed using paired t tests. Asterisks indicate statistical significance: ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001, ∗∗∗∗ p < 0.0001.
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Aluminum exposure triggers mitochondrial dysfunction, oxidative damage accumulation and apoptosis in mouse zygotes (A) Representative images of mitochondrial distribution in zygotes of the control and treatment groups by immunofluorescence staining. Red, mitochondria; blue, DNA. Scale bars, 20 μm. (B) Relative fluorescence intensity and abnormal rate of mitochondria. The relative fluorescence intensity: control, n = 47; AlCl 3 , n = 50; ∗∗ p < 0.005; abnormal rate: control, n = 47; AlCl 3 , n = 50; ∗∗∗ p < 0.0005. (C) TMRE levels in zygotes of the control and treatment groups by immunofluorescence staining. Red, TMRE; blue, DNA. Scale bars, 20 μm. (D) Relative fluorescence intensity of TMRE. Control, n = 45; AlCl 3 , n = 46; ∗ p < 0.05. (E) ROS-positive rate in zygotes of the control and treatment groups at 5.5 h, 6 h, 9 h, and 12 h post-fertilization by immunofluorescence staining. Green, ROS. Scale bars, 80 μm. (5.5 h corresponds to 30 min after AlCl 3 treatment, 6 h to 1 h, 9 h–4 h, and 12 h–7 h after AlCl 3 treatment). (F) ROS-positive rate in zygotes at different time points post-fertilization. 5.5 h: control, n = 39; AlCl 3 , n = 38; ∗∗∗ p < 0.0005; 6 h: control, n = 45; AlCl 3 , n = 47; ∗∗ p < 0.005; 9 h: control, n = 41; AlCl 3 , n = 42; ∗ p < 0.05; 12 h: control, n = 38; AlCl 3 , n = 46; ∗∗∗∗ p < 0.0001. (G) The mRNA expression level of Cox1 . ∗∗∗ p < 0.0005. (H) 8-OHdG levels in zygotes of the control and treatment groups by immunofluorescence staining. Red, 8-OHdG; blue, DNA. Scale bars, 20 μm. (I) Relative fluorescence intensity of 8-OHdG. Control, n = 41; AlCl 3 , n = 39; ∗∗ p < 0.005. (J) The 4-HNE levels in zygotes of the control and treatment groups by immunofluorescence staining. Red, 4-HNE; blue, DNA. Scale bars, 20 μm. (K) Relative fluorescence intensity of 4-HNE. Control, n = 39; AlCl 3 , n = 41; ∗∗∗∗ p < 0.0001. (L) The mRNA expression levels of oxidative stress-related genes. ∗∗ p < 0.005, ∗∗ p < 0.01, ∗ p < 0.05, ∗∗∗ p < 0.0005. (M) Representative images of early apoptosis in control and AlCl 3 -exposed groups by immunofluorescence staining. Green, annexin-V. Scale bars, 20 μm. (N) Apoptosis rate of zygotes. Control, n = 56; AlCl 3 , n = 50; ∗∗ p < 0.005. (O) The mRNA expression levels of apoptosis-related genes. ∗∗ p < 0.01, ∗∗ p < 0.005, ∗ p < 0.05. Data are presented as mean ± SEM. All experiments were performed in three independent biological replicates, with three technical replicates per biological replicate; mouse zygotes were used as research subjects. n represents the number of zygotes analyzed. Statistical analysis was performed using paired t tests. Asterisks indicate statistical significance: ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001, ∗∗∗∗ p < 0.0001.

Journal: iScience

Article Title: Aluminum exposure impairs nuclear envelope breakdown for mouse zygote formation

doi: 10.1016/j.isci.2026.115807

Figure Lengend Snippet: Aluminum exposure triggers mitochondrial dysfunction, oxidative damage accumulation and apoptosis in mouse zygotes (A) Representative images of mitochondrial distribution in zygotes of the control and treatment groups by immunofluorescence staining. Red, mitochondria; blue, DNA. Scale bars, 20 μm. (B) Relative fluorescence intensity and abnormal rate of mitochondria. The relative fluorescence intensity: control, n = 47; AlCl 3 , n = 50; ∗∗ p < 0.005; abnormal rate: control, n = 47; AlCl 3 , n = 50; ∗∗∗ p < 0.0005. (C) TMRE levels in zygotes of the control and treatment groups by immunofluorescence staining. Red, TMRE; blue, DNA. Scale bars, 20 μm. (D) Relative fluorescence intensity of TMRE. Control, n = 45; AlCl 3 , n = 46; ∗ p < 0.05. (E) ROS-positive rate in zygotes of the control and treatment groups at 5.5 h, 6 h, 9 h, and 12 h post-fertilization by immunofluorescence staining. Green, ROS. Scale bars, 80 μm. (5.5 h corresponds to 30 min after AlCl 3 treatment, 6 h to 1 h, 9 h–4 h, and 12 h–7 h after AlCl 3 treatment). (F) ROS-positive rate in zygotes at different time points post-fertilization. 5.5 h: control, n = 39; AlCl 3 , n = 38; ∗∗∗ p < 0.0005; 6 h: control, n = 45; AlCl 3 , n = 47; ∗∗ p < 0.005; 9 h: control, n = 41; AlCl 3 , n = 42; ∗ p < 0.05; 12 h: control, n = 38; AlCl 3 , n = 46; ∗∗∗∗ p < 0.0001. (G) The mRNA expression level of Cox1 . ∗∗∗ p < 0.0005. (H) 8-OHdG levels in zygotes of the control and treatment groups by immunofluorescence staining. Red, 8-OHdG; blue, DNA. Scale bars, 20 μm. (I) Relative fluorescence intensity of 8-OHdG. Control, n = 41; AlCl 3 , n = 39; ∗∗ p < 0.005. (J) The 4-HNE levels in zygotes of the control and treatment groups by immunofluorescence staining. Red, 4-HNE; blue, DNA. Scale bars, 20 μm. (K) Relative fluorescence intensity of 4-HNE. Control, n = 39; AlCl 3 , n = 41; ∗∗∗∗ p < 0.0001. (L) The mRNA expression levels of oxidative stress-related genes. ∗∗ p < 0.005, ∗∗ p < 0.01, ∗ p < 0.05, ∗∗∗ p < 0.0005. (M) Representative images of early apoptosis in control and AlCl 3 -exposed groups by immunofluorescence staining. Green, annexin-V. Scale bars, 20 μm. (N) Apoptosis rate of zygotes. Control, n = 56; AlCl 3 , n = 50; ∗∗ p < 0.005. (O) The mRNA expression levels of apoptosis-related genes. ∗∗ p < 0.01, ∗∗ p < 0.005, ∗ p < 0.05. Data are presented as mean ± SEM. All experiments were performed in three independent biological replicates, with three technical replicates per biological replicate; mouse zygotes were used as research subjects. n represents the number of zygotes analyzed. Statistical analysis was performed using paired t tests. Asterisks indicate statistical significance: ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001, ∗∗∗∗ p < 0.0001.

Article Snippet: 8-OHdG antibody , MedChemExpress , Cat# HY- P81140 ; RRID: AB_3103069.

Techniques: Control, Immunofluorescence, Staining, Fluorescence, Expressing